CAS 6066-82-6 99% N-Hydroxysuccinimide NHS

[Name]

N-Hydroxysuccinimide

[CAS]

6066-82-6

[Synonyms]

1-HYDROXY-2,5-PYRROLIDINEDIONE
1-HYDROXY-PYRROLIDINE-2,5-DIONE
2,5-PYRROLIDINEDIONE, 1-HYDROXY-
4-HYDROXY-2,5-PYRROLIDINEDIONE
AKOS 91864
HONSU
HOSU
NHS
N-HYDROXY-2,5-PYRROLIDINEDIONE
N-HYDROXYSUCCINIMDE
N-HYDROXYSUCCINIMIDE
N-HYDROXYSUCCINIMIDE POLYMER-BOUND
1-hydroxy-5-pyrrolidinedione
1-Hydroxysuccinimide
5-Pyrrolidinedione,1-hydroxy-2
Hydroxysuccinimide
Succinimide, N-hydroxy-
HOSu~1-Hydroxy-2,5-pyrrolidinedione
N-Hydroxysuccinimide (HOSu)
N-HYDROXYSUCCINAMIDE

[EINECS(EC#)]

228-001-3

[Molecular Formula]

C4H5NO3

[MDL Number]

MFCD00005516

[Molecular Weight]

115.09

[MOL File]

6066-82-6.mol

Chemical Properties
[Appearance]

White to pale yellow

[Melting point ]

95-98 °C(lit.)

[Boiling point ]

215.33°C (rough estimate)

[density ]

1.4769 (rough estimate)

[vapor pressure ]

0Pa at 25℃

[refractive index ]

1.4080 (estimate)

[storage temp. ]

2-8°C

[solubility ]

DMSO (Soluble), Methanol (Slightly)

[form ]

Liquid or Solid

[pka]

7.81±0.20(Predicted)

[color ]

Clear yellow-brown to brown

[PH]

5-7 (50g/l, H2O, 20℃)

[Stability:]

Stable. Incompatible with strong oxidizing agents, acid chlorides, acid anhydrides, strong bases. Protect from moisture.

[Water Solubility ]

SOLUBLE

[Sensitive ]

Hygroscopic

[Usage]

Additive used in the carbodiimide method for improved amidations and peptide couplings.

[Detection Methods]

T,NMR

[BRN ]

113913

[InChIKey]

NQTADLQHYWFPDB-UHFFFAOYSA-N

[LogP]

-2.01

[Uses]

N-hydroxysuccinimide (NHS) is often used to assist carbodiimide-mediated peptide coupling by forming an active ester intermediate via condensation of the surface carboxyl group and NHS. The NHS-reactive ester intermediate is susceptible to nucleophilic attack by primary amines and results in the formation of stable amide bonds between the biomaterial surface and the N-terminus of the peptide.

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